Potassium Carbonate → ethyl 1-(4-ethylphenyl)-1H-imidazole-5-carboxylate

HRID 72714

反応式

HRID 72714 の反応式
[CH2:1]([C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][CH:4]=1)[CH3:2].O=[CH:11][C:12]([O:14][CH2:15][CH3:16])=[O:13].C(=O)([O-])[O-].[K+].[K+].CC1C=CC(S([CH2:33][N+:34]#[C-:35])(=O)=O)=CC=1>C(O)C>[CH2:1]([C:3]1[CH:9]=[CH:8][C:6]([N:7]2[C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:35][N:34]=[CH:33]2)=[CH:5][CH:4]=1)[CH3:2]

参加物

6

反応物 4

HCID 11430Potassium CarbonateHCID 115044-EthylanilineHCID 70211Ethyl oxoacetateHCID 161915Tosylmethyl isocyanide

生成物 1

HCID 71093623ethyl 1-(4-ethylphenyl)-1H-imidazole-5-carboxylate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4-Ethylaniline (2.08 mL, 16.6 mmol) and ethyl oxoacetate (50% solution in toluene, 3.30 mL, 16.6 mmol) were combined in ethanol (40 mL) and stirred at room temperature for 3 hours. Potassium carbonate (5.75 g, 41.6 mmol) and isocyanomethyl 4-methylphenyl sulfone (98%, 3.98 g, 20.0 mmol) were added and the reaction mixture was heated to reflux for 3 hours. After cooling to room temperature, the reaction mixture was filtered through Celite. The filtrate was concentrated in vacuo, dissolved in ethyl acetate, washed with water, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. Purification via silica gel chromatography (Gradient: 0% to 33% ethyl acetate in heptane) afforded the product as a clear brown oil that solidified upon standing. Yield: 3.03 g, 12.4 mmol, 75%. LCMS m/z 245.0 (M+1). 1H NMR (400 MHz, CDCl3) δ 1.24 (t, J=7.1 Hz, 3H), 1.29 (t, J=7.6 Hz, 3H), 2.73 (q, J=7.6 Hz, 2H), 4.21 (q, J=7.1 Hz, 2H), 7.27 (br AB quartet, JAB=8.6 Hz, ΔνAB=24 Hz, 4H), 7.66 (d, J=1.1 Hz, 1H), 7.85 (d, J=1.1 Hz, 1H).

後処理

  1. temperaturethe reaction mixture was heated
  2. temperatureto reflux for 3 hours
  3. temperatureAfter cooling to room temperature
  4. filtrationthe reaction mixture was filtered through Celite
  5. concentrationThe filtrate was concentrated in vacuo
  6. dissolutiondissolved in ethyl acetate
  7. washwashed with water
  8. dry with materialdried over magnesium sulfate
  9. filtrationfiltered
  10. concentrationconcentrated under reduced pressure
  11. customPurification via silica gel chromatography (Gradient: 0% to 33% ethyl acetate in heptane)

出典と根拠

ORDレコード
ord-c2c1bc9e250c408ea7c3640a79ae49a8
出典データセット
uspto-grants-2014_09
特許番号
US08829010B2

関連ノート

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