Sodium Bicarbonate → 1-(4-Methyl-5-oxazolyl)-1-phenylmethanol
反応式
[CH3:1][C:2]1[N:3]=[CH:4][O:5][C:6]=1[CH:7]=[O:8].[C:9]1([Li])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(=O)([O-])O.[Na+]>O1CCCC1>[CH3:1][C:2]1[N:3]=[CH:4][O:5][C:6]=1[CH:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[OH:8]参加物
5
実験手順
4-Methyl -5-oxazolecarbaldehyde (600 m g) in dry tetrahydrofuran (10 ml) was added dropwise to a stirred solution of phenyllithium (2.0M solution in cyclohexane and diethyl ether, 2.8 ml) in tetrahydrofuran (20 ml) at -70° C. under an atmosphere of dry nitrogen. After 1 hour the mixture was allowed to warm to room temperature. After a further 1 hour saturated aqueous sodium hydrogen carbonate was added and the mixture was extracted with ethyl acetate. The product was purified by flash chromatography to yield the title compound.
後処理
- extractionthe mixture was extracted with ethyl acetate
- customThe product was purified by flash chromatography
出典と根拠
- ORDレコード
- ord-2b3b0e2ba3bc4efe81419f52aea203b9
- 出典データセット
- uspto-grants-1998_01
- 特許番号
- US05712299
反応ノート
読み込み中…