反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]#[N:9])[CH:2]=1.[OH-].[Na+].C[O:13][N:14]=O.S(=O)(=O)(O)O.N([O-])=O.[Na+]>CO.O>[N:14](=[C:7]([C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)[C:8]#[N:9])[OH:13]参加物
8
反応条件
- 温度
- 0 °C
実験手順
3-pyridylacetonitrile (47.2 g, 400 mmol) was dissolved in a solution of sodium hydroxide (16 g, 400 mmol) in methanol (100 ml). Methylnitrite, generated by dropping a solution of concentrated sulphuric acid (12.8 ml) and water (26 ml) to a solution of sodium nitrite (33.2 g, 480 mmol) in water (20 ml) and methanol (20 ml), was bobled through the 3-pyridylacetonitrile solution at 0° C. The reaction mixture was stirred at 0° C. for 1 h and the precipitate collected by filtration. The precipitate was washed with a little methanol to give the wanted product in 70% (41.1 g) yield. M+ : 147.
後処理
- filtrationthe precipitate collected by filtration
- washThe precipitate was washed with a little methanol
- customto give the wanted product in 70% (41.1 g)
- customyield
出典と根拠
- ORDレコード
- ord-d523e78b3b704463bb832fb2d59a95bc
- 出典データセット
- uspto-grants-1998_01
- 特許番号
- US05712297
関連ノート
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