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Diisopropylethylamine → Ethyl 4-(2-isopropyl-1H-imidazol-1-yl)-3-nitrobenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 1H-Imidazole, 2-(1-methylethyl)- | HCID 123457 | — |
| 反応物 | Ethyl 4-fluoro-3-nitrobenzoate | HCID 21277355 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Ethyl 4-(2-isopropyl-1H-imidazol-1-yl)-3-nitrobenzoate | HCID 59198553 | 81.7% |
反応手順
A mixture of ethyl 4-fluoro-3-nitrobenzoate 4.26 g, 2-isopropylimidazole 2.20 g, N,N-diisopropylethylamine 5.2 mL and acetonitrile 40 mL was heated under reflux for 24 hours. After distilling the solvent off, water was added to the residue and extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and removed of the solvent by distillation, to provide 4.95 g of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829000B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-5ec2d21edca24238b918011c1f187676 |
| 出典メモ | uspto-grants-2014_09 |