反应详情

A mixture of ethyl 4-fluoro-3-nitrobenzoate 4.26 g, 2-isopropylimidazole 2.20 g, N,N-diisopropylethylamine 5.2 mL and acetonitrile 40 mL was heated under reflux for 24 hours. After distilling the solvent off, water was added to the residue and extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and removed of the solvent by distillation, to provide 4.95 g of the title compound.

1. temperaturewas heated
2. temperatureunder reflux for 24 hours
3. distillationAfter distilling the solvent off, water
4. additionwas added to the residue
5. extractionextracted with ethyl acetate
6. washThe organic layer was washed with brine
7. dry with materialdried over magnesium sulfate
8. customremoved of the solvent by distillation