Acetic Anhydride → O-Ethylacetanilide

HRID 72818

反応式

HRID 72818 の反応式
[CH2:1]([C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[NH2:5])[CH3:2].[C:10](OC(=O)C)(=[O:12])[CH3:11]>O>[C:10]([NH:5][C:4]1[CH:6]=[CH:7][CH:8]=[CH:9][C:3]=1[CH2:1][CH3:2])(=[O:12])[CH3:11]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 113572-Ethylaniline

生成物 1

HCID 36332O-Ethylacetanilide収率 92%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

commercial 2-ethylaniline (50 mL, 0.40 mol) was dissolved in acetic anhydride (160 mL, 1.70 mol) and stirred at room temperature for 2 h. Then the reaction mixture was poured into H2O, the whole was extracted with ethyl acetate (2×200 mL). The combined organic extracts were washed with 5% aqueous NaHCO3, brine, dried (K2CO3), filtered and concentrated to provide the title compound as a white solid (60.0 g, 92%).

後処理

  1. extractionthe whole was extracted with ethyl acetate (2×200 mL)
  2. washThe combined organic extracts were washed with 5% aqueous NaHCO3, brine
  3. dry with materialdried (K2CO3)
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-b144dcdb61a34243871c8d2b98bb850f
出典データセット
uspto-grants-2014_09
特許番号
US08828986B2

関連ノート

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