4-Hydroxy-4-methylcyclohexanone → (4-Methoxy-4 methyl-cyclohexylidene)-acetic acid methyl ester
反応式
[CH3:1][O:2][C:3]([CH2:5]P(OC)(OC)=O)=[O:4].[Li][CH2:13]CCC.[OH:17][C:18]1([CH3:25])[CH2:23][CH2:22][C:21](=O)[CH2:20][CH2:19]1>COCCOC>[CH3:1][O:2][C:3](=[O:4])[CH:5]=[C:21]1[CH2:22][CH2:23][C:18]([O:17][CH3:13])([CH3:25])[CH2:19][CH2:20]1参加物
5
反応条件
- 温度
- 0 °C
実験手順
A mixture of trimethyl phosphonoacetate (9.11 mL, 56 mmol) and (40 mL, 64 mmol) of n-BuLi (1.6N) in DME (60 mL) is stirred for 10 minutes at 0° C. 4-Hydroxy-4-methyl-cyclohexanone (8 g, 56 mmol) was added and the mixture stirred 2.5 hours at 0° C. until TCL indicated complexion of the reaction. Product was obtained after extraction with dichloromethane (7.71 g, 69%).
後処理
- stirringthe mixture stirred 2.5 hours at 0° C. until TCL
- customcomplexion of the reaction
- customProduct was obtained
- extractionafter extraction with dichloromethane (7.71 g, 69%)
出典と根拠
- ORDレコード
- ord-d765b0a07c0e4665acc96698a2b2a4ee
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08829029B2
反応ノート
読み込み中…