Ethanolamine → N-(2-hydroxyethyl)-N-(2-hexyl-2-hydroxyethyl)amine

HRID 728632

反応式

HRID 728632 の反応式
[O:1]1[CH:3]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])[CH2:2]1.[CH2:10]([CH2:12][NH2:13])[OH:11]>>[OH:11][CH2:10][CH2:12][NH:13][CH2:2][CH:3]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])[OH:1]

参加物

3

反応物 2

HCID 700EthanolamineHCID 181262-Hexyloxirane

生成物 1

HCID 19936261N-(2-hydroxyethyl)-N-(2-hexyl-2-hydroxyethyl)amine収率 93%

実験手順

50 g (0.39 mmole) of 1,2-epoxy-octane are added dropwise to 250 cm3 (4 moles) of ethanolamine at 100° C. Heating is maintained for 1 h after the addition is complete, then the excess ethanolamine is distilled in a vacuum. The residue is recrystallised from 600 cm3 of hexane, after filtration and drying. The solid residue obtained weighs 69 g (melting point 45° C., yield=93% Rf=0.62 silica/butanol/H2O/acetic acid/50/25/11).

後処理

  1. temperatureHeating
  2. temperatureis maintained for 1 h
  3. additionafter the addition
  4. distillationthe excess ethanolamine is distilled in a vacuum
  5. customThe residue is recrystallised from 600 cm3 of hexane
  6. filtrationafter filtration
  7. customdrying
  8. customThe solid residue obtained

出典と根拠

ORDレコード
ord-268503a4e4a24e7ab9db3468d77580f8
出典データセット
uspto-grants-1991_09
特許番号
US05049667

関連ノート

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