反応式
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[C@@H:11]2[CH2:15][C@H:14]([CH2:16][OH:17])[CH:13]=[CH:12]2)=[C:4](Cl)[N:3]=1.[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1.[OH-].[Na+]>C(O)C>[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[C@@H:11]2[CH2:15][C@H:14]([CH2:16][OH:17])[CH:13]=[CH:12]2)=[C:4]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[N:3]=1参加物
5
実験手順
A solution of (±)-cis-4-(-2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol (0.531 g, 2.00 mmol) from Example 4 and morpholine (0.526 g, 6.04 mmol) in ethanol (6 mL) was stirred at reflux for 1 hour. The reaction mixture was allowed to cool to room temperature before the addition of 2 mL of 1.0 N NaOH. Concentration of the mixture afforded the crude product which was purified by elution from a silica gel column using 5% methanol in chloroform (0.62 g, 98%). Crystallization of such a sample from ethanol-water gave a white powder; m.p. 165-167° C.
後処理
- temperatureat reflux for 1 hour
出典と根拠
- ORDレコード
- ord-a582c7518406493b858274d68fa554dc
- 出典データセット
- uspto-grants-1991_09
- 特許番号
- US05049671
関連ノート
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