Phosphoric Acid → HCID 67689897、化合物

反応式

[O:1]1[CH:3]([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][O:14][CH3:15])=[CH:8][CH:7]=2)[CH2:2]1.Cl.[CH3:17][S:18]([NH:21][C:22]1[CH:35]=[CH:34][C:25]([C:26]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[O:27])=[CH:24][CH:23]=1)(=[O:20])=[O:19].[OH-].[Na+].[P:38](=[O:42])([OH:41])([OH:40])[OH:39]>>[P:38](=[O:39])([OH:42])([OH:41])[OH:40].[OH:1][CH:3]([CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][O:14][CH3:15])=[CH:8][CH:7]=1)[CH2:2][N:31]1[CH2:32][CH2:33][N:28]([C:26](=[O:27])[C:25]2[CH:34]=[CH:35][C:22]([NH:21][S:18]([CH3:17])(=[O:20])=[O:19])=[CH:23][CH:24]=2)[CH2:29][CH2:30]1

参加物

反応物 4

HCID 1004Phosphoric Acid

HCID 14798Sodium Hydroxide

HCID 92515((p-(2-Methoxyethyl)phenoxy)methyl)oxirane

HCID 679387821-[4-[(Methylsulfonyl)amino]benzoyl]piperazine hydrochloride

生成物 1

HCID 67689897HCID 67689897、化合物

実験手順

Add 2.64 g (.013 mol) of 1,2-epoxy-3-[4-(2-methoxyethyl)phenoxy]propane to a solution of 3.86 (12 mmol) 1-[4-[(methylsulfonyl)amino]benzoyl]piperazine hydrochloride in 50 mL MeOHand 13 mL 1 N NaOH. Heat the resultant solution at 50° C. for about 24 h. Cool the solution to room temperature and evaporate the solvents. Dissolve the resultant oil in ethanol and acidify with one equivalent of phosphoric acid. Remove the solvents to obtain the title compound.