1-[[2-[4-(1H-Imidazol-1-yl)phenoxy]ethyl](phenylmethyl)amino]-3-phenoxy-2-propanol → 1-[[2-[4-(1H-Imidazol-1-yl)phenoxy]ethyl]amino]-3-phenoxy-2-propanol

HRID 728833ノート

反応式

HRID 728833 の反応式
[N:1]1([C:6]2[CH:33]=[CH:32][C:9]([O:10][CH2:11][CH2:12][N:13](CC3C=CC=CC=3)[CH2:14][CH:15]([OH:24])[CH2:16][O:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1>CO.[Pd]>[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([O:10][CH2:11][CH2:12][NH:13][CH2:14][CH:15]([OH:24])[CH2:16][O:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:32][CH:33]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

参加物

4

反応物 1

HCID 539690031-[[2-[4-(1H-Imidazol-1-yl)phenoxy]ethyl](phenylmethyl)amino]-3-phenoxy-2-propanol

生成物 1

HCID 147399051-[[2-[4-(1H-Imidazol-1-yl)phenoxy]ethyl]amino]-3-phenoxy-2-propanol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 5.5 g (12.4 mmol) 1-[[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl](phenylmethyl)amino]-3-phenoxy-2-propanol in 25 mL methanol is suspended 1.0 g 10% palladium on carbon. The reaction mixture is hydrogenated at 50 psi in a Parr Hydrogenator. Follow the progress of the reaction by thin-layer chromatography on silica gel (methylene chloride:methanol, 9:1). At the completion of the reaction, thecatalyst is filtered and the solvents are removed in vacuo. The isolated oil is taken up in methylene chloride, dried over anhydrous Na2SO4, filtered and the solvents are removed to give the title compound.

後処理

  1. customthe progress of the reaction by thin-layer chromatography on silica gel (methylene chloride:methanol, 9:1)
  2. customAt the completion of the reaction, thecatalyst
  3. filtrationis filtered
  4. customthe solvents are removed in vacuo
  5. dry with materialdried over anhydrous Na2SO4
  6. filtrationfiltered
  7. customthe solvents are removed

出典と根拠

ORDレコード
ord-8fdf8ab75a6a46d69ddb89040956c604
出典データセット
uspto-grants-1991_09
特許番号
US05051423

反応ノート

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