Hydrochloric Acid → 2-Piperazinecarboxylic acid,4-phenyl-1-(phenylmethyl)-

HRID 728924ノート

反応式

HRID 728924 の反応式
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:9]([C:20](N)=[O:21])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-:23].[K+].Cl.O>C(O)CO>[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:9]([C:20]([OH:21])=[O:23])[CH2:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 109900971-Benzyl-4-phenyl-piperazine-2-carboxamide

生成物 1

HCID 149988012-Piperazinecarboxylic acid,4-phenyl-1-(phenylmethyl)-

試薬・触媒・溶媒 1

HCID 174Ethylene Glycol溶媒

実験手順

Suspend 4-phenyl-1-(phenylmethyl)-2-piperazinecarboxamide (14.5 g, 49 mmol)in ethylene glycol (400 mL) and add potassium hydroxide (27.5 g, 490 mmol).Heat this mixture to 150° C. for 18 h. After this time, remove the solvent in vacuo. Add 6M hydrochloric acid (81.5 mL, 0.49 mol) and water (300 mL) and filter the resultant solid to obtain the title compound.

後処理

  1. customAfter this time, remove the solvent in vacuo
  2. filtrationfilter the resultant solid

出典と根拠

ORDレコード
ord-d1cdf371fdc84ebdaeb2c748844826df
出典データセット
uspto-grants-1991_09
特許番号
US05051422

反応ノート

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