Sodium Hydroxide → 1-(2-Methoxyphenyl)-4-amino-6-methoxy-2,3-dihydropyrrolo[3,2-c]quinoline

温度

230 °C

1-(2-Methoxyphenyl)-4-oxo-6-methoxy-2,3,4,5-tetrahydropyrrolo[3,2-c]quinoline (1.5 g) and phenyl phosphorodiamidate (2.5 g) were fused at 230° C. After 45 minutes the mixture was diluted with diphenyl ether (10 ml), further phenyl phosphorodiamidate (2 g) added, and heated for a further 15minutes at 230° C. Aqueous sodium hydroxide was added and the product extracted into dichloromethane. Chromatography (silica gel. 2.5-4%methanolic ammonia in dichloromethane) to remove unchanged starting material was followed by recrystallisation from ethanol/ethyl acetate to yield 1-(2-methoxyphenyl)-4-amino-6-methoxy-2,3-dihydropyrrolo[3,2-c]quinoline (0.36 g), m.p. 244°-247° (dec).

1. customwere fused at 230° C
2. additionadded
3. extractionthe product extracted into dichloromethane
4. customChromatography (silica gel. 2.5-4%methanolic ammonia in dichloromethane) to remove unchanged
5. customwas followed by recrystallisation from ethanol/ethyl acetate

ORDレコード

ord-cdad40774a3b4704af12b9b0a2d3f3f8

出典データセット

uspto-grants-1991_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05051508