5-Chloro-1-benzofuran-2-carboxylic acid → 5-Chloro-1-benzofuran

HRID 7293

反応式

HRID 7293 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8](C(O)=O)=[CH:7][C:6]=2[CH:13]=1>CN1CCCC1=O.[Cu]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]=[CH:7][C:6]=2[CH:13]=1

参加物

4

反応物 1

HCID 9378385-Chloro-1-benzofuran-2-carboxylic acid

生成物 1

HCID 900135-Chloro-1-benzofuran収率 418.7%

試薬・触媒・溶媒 2

HCID 23978Copper触媒HCID 13387N-methyl-2-pyrrolidone溶媒

反応条件

温度
250 °C

実験手順

To a solution of 5-chloro-1-benzofuran-2-carboxylic acid (0.2 g) in 1-methyl-2-pyrrolidinone (2 ml) was added copper granules (0.2 g). The reaction mixture was heated at 250° C. for 3.5 min in a microwave. The reaction vessel was cooled to room temperature and the mixture combined with four other similar mixtures and the combined mixtures partitioned between water and diethyl ether. The organic layer was washed with water and brine, dried (over magnesium sulphate) and concentrated under reduced pressure to give the title compound (0.65 g) as a yellow oil.

後処理

  1. temperatureThe reaction vessel was cooled to room temperature
  2. customthe combined mixtures partitioned between water and diethyl ether
  3. washThe organic layer was washed with water and brine
  4. dry with materialdried (over magnesium sulphate)
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-a765f630bfcc4d368621ba25c966168e
出典データセット
uspto-grants-2006_08
特許番号
US07084139B2

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