5-Chloro-1-benzofuran-2-carboxylic acid → 5-Chloro-1-benzofuran
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8](C(O)=O)=[CH:7][C:6]=2[CH:13]=1>CN1CCCC1=O.[Cu]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]=[CH:7][C:6]=2[CH:13]=1参加物
4
反応条件
- 温度
- 250 °C
実験手順
To a solution of 5-chloro-1-benzofuran-2-carboxylic acid (0.2 g) in 1-methyl-2-pyrrolidinone (2 ml) was added copper granules (0.2 g). The reaction mixture was heated at 250° C. for 3.5 min in a microwave. The reaction vessel was cooled to room temperature and the mixture combined with four other similar mixtures and the combined mixtures partitioned between water and diethyl ether. The organic layer was washed with water and brine, dried (over magnesium sulphate) and concentrated under reduced pressure to give the title compound (0.65 g) as a yellow oil.
後処理
- temperatureThe reaction vessel was cooled to room temperature
- customthe combined mixtures partitioned between water and diethyl ether
- washThe organic layer was washed with water and brine
- dry with materialdried (over magnesium sulphate)
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-a765f630bfcc4d368621ba25c966168e
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07084139B2
反応ノート
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