4-tert-Butylbenzaldehyde → HCID 178440764、化合物

反応式

[N:1]1[CH:6]=[C:5]([NH2:7])[C:4]([NH2:8])=[C:3]([NH2:9])[CH:2]=1.[C:10]([C:14]1[CH:21]=[CH:20][C:17]([CH:18]=O)=[CH:16][CH:15]=1)([CH3:13])([CH3:12])[CH3:11]>C(O)(C)C.[Pd]>[C:10]([C:14]1[CH:15]=[CH:16][C:17]([C:18]2[NH:8][C:4]3[C:5]([NH2:7])=[CH:6][N:1]=[CH:2][C:3]=3[N:9]=2)=[CH:20][CH:21]=1)([CH3:13])([CH3:12])[CH3:11]

参加物

実験手順

Pyridine-3,4,5-triamine 3 (100 mg, 0.81 mmol) was dissolved in isopropanol (4 ml) with Pd/C (20 mg of 10% powder). 4-t-butyl benzaldehyde (150 mg, 0.92 mmol) was added, and this mixture was refluxed for 48 hours. The reaction mixture was filtered through CELITE to remove the palladium, and the crude was purified by HPLC (Method E) to yield the title compound 4 (81 mg (37%), 0.3 mmol). 1H NMR (DMSO-d6): δ 8.64 (bs, 1H), 8.18 (d, J=8.6 Hz, 2H), 7.75 (s,1H), 7.69 (d, J=8.6 Hz, 2H), 6.30-6.61 (bs, 2H), 1.35 (s, 9H). MS (ESI-POS): [M+H]+=266.