Perchloric Acid → HCID 59699856、化合物
反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:9]([CH:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=[CH:10]OC)[C:5]([NH2:8])=[N:6][CH:7]=1.Cl(O)(=O)(=O)=O>O1CCOCC1>[Br:1][C:2]1[CH:3]=[C:4]2[C:9]([CH:13]3[CH2:17][CH2:16][CH2:15][CH2:14]3)=[CH:10][NH:8][C:5]2=[N:6][CH:7]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
A mixture of 5-bromo-3-(1-cyclopentyl-2-methoxy-vinyl)-pyridin-2-ylamine (116.9 mg, 0.39 mmol) and perchloric acid (0.11 mL) in dioxane (1 mL) was heated at 80° C. for 2 hrs. Solvents were evaporated and the residue was washed with a solution of 2M sodium carbonate (5 mL). A precipitate was formed and filtered off. It was washed with water and dried to afford the product 5-bromo-3-cyclopentyl-1H-pyrrolo[2,3-b]pyridine (69.8 mg, 67% yield) as a brown solid. MS: m/z 265/266 [MH+].
後処理
- customSolvents were evaporated
- washthe residue was washed with a solution of 2M sodium carbonate (5 mL)
- customA precipitate was formed
- filtrationfiltered off
- washIt was washed with water
- customdried
出典と根拠
- ORDレコード
- ord-d6ffca41ed0942c985ed900e925c29a1
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07582637B2
反応ノート
読み込み中…