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Trimethylacetamide → 2-tert-Butyl-4-(4-fluorophenyl)oxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trimethylacetamide | HCID 12957 | — |
| 反応物 | 2-Bromo-1-(4-fluorophenyl)ethan-1-one | HCID 96749 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2-tert-Butyl-4-(4-fluorophenyl)oxazole | HCID 66869043 | 1,254.2% |
反応手順
Reflux a solution of commercially available 2-bromo-4′-fluoroacetophenone (100.00 g, 460 mmol), 2,2-dimethyl-propionamide (93.06 g, 20 mmol) in 1,4-dioxane (600 mL) for 2 days. Filter precipitate, concentrate filtrate, and purify (silica gel chromatography, eluting with hexanes:EtOAc 60:1) to give the title compound (55 g, 55%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07582652B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-52788692ddab4fcba992ec967028d476 |
| 出典メモ | uspto-grants-2009_09 |