Water → 5-Amino-1-((4-fluorophenyl)(phenyl)methyl)-1H-pyrrole-3-carbonitrile

HRID 730424ノート

反応式

HRID 730424 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:15][CH:16]=[C:17]([CH2:20][C:21]#[N:22])[C:18]#[N:19])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.[O-]CC.[K+].O>O1CCCC1.C(O)C>[NH2:22][C:21]1[N:15]([CH:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:16]=[C:17]([C:18]#[N:19])[CH:20]=1

参加物

6

反応物 3

HCID 962WaterHCID 23670592Potassium ethoxideHCID 690558642-({[(4-Fluorophenyl)(phenyl)methyl]amino}methylidene)butanedinitrile

生成物 1

HCID 690583295-Amino-1-((4-fluorophenyl)(phenyl)methyl)-1H-pyrrole-3-carbonitrile

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 2-({[(4-fluorophenyl)(phenyl)methyl]amino}methylene)butanedinitrile (13.9 g, 47.7 mmol) in tetrahydrofuran (50 ml) and ethanol (50 ml) was slowly added potassium ethoxide (7.05 g, 83.8 mmol), the mixture was stirred at room temperature for 1 hour and poured into iced water. The product was extracted with ethyl acetate, the extract was washed with water, dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure to give the objective product as oily matter.

後処理

  1. extractionThe product was extracted with ethyl acetate
  2. washthe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure
  5. customto give the objective product as oily matter

出典と根拠

ORDレコード
ord-3fa949b04f154c71aa98cf877af98d0e
出典データセット
uspto-grants-2009_09
特許番号
US07582651B2

反応ノート

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