Sodium Hydroxide → 5-Bromo-2-methoxy-4-methylbenzoic acid
反応式
[Br:1][C:2]1[C:3]([CH3:14])=[CH:4][C:5]([O:12][CH3:13])=[C:6]([CH:11]=1)[C:7]([O:9]C)=[O:8].[OH-].[Na+]>CCO.O>[Br:1][C:2]1[C:3]([CH3:14])=[CH:4][C:5]([O:12][CH3:13])=[C:6]([CH:11]=1)[C:7]([OH:9])=[O:8]参加物
4
実験手順
Methyl 5-bromo-2-methoxy-4-methylbenzoate (11.64 g, 0.045 mol) was dissolved in a mixture of EtOH:H2O (1:1 ratio, 150 mL), NaOH (5.8 g, 0.145 mol) was added and reaction mixture was refluxed for 30 min. The EtOH solvent was removed from the mixture by distillation which leads to precipitation of the desired product as its sodium salt. The residue was diluted with H2O (75 mL) and the pH was adjusted to ˜2 with concentrated HCl. The precipitate was collected by filtration, washed with H2O (3×50 mL) and air dried to give pure 5-bromo-2-methoxy-4-methylbenzoic acid 12a (9 g, 82% yield) as a beige solid.
後処理
- additionwas added
- customreaction mixture
- temperaturewas refluxed for 30 min
- customThe EtOH solvent was removed from the mixture by distillation which
- customleads to precipitation of the desired product as its sodium salt
- additionThe residue was diluted with H2O (75 mL)
- filtrationThe precipitate was collected by filtration
- washwashed with H2O (3×50 mL) and air
- customdried
出典と根拠
- ORDレコード
- ord-91ede3a32f1c487d88b729e501ab50b8
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07582766B2
反応ノート
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