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Diisopropylethylamine → 4-Bromo-2-[4-(3-chloropyridin-2-yl)piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 4-bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazole | HCID 11594585 | — |
| 反応物 | 1-(3-Chloropyridin-2-yl)piperazine hydrochloride | HCID 20455074 | — |
| 生成物 | 4-Bromo-2-[4-(3-chloropyridin-2-yl)piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole | HCID 57835161 | — |
反応手順
The benzoimidazole from step (b) above (210 mg, 0.7 mmol), 1-(3-chloropyridin-2-yl)piperazine hydrochloride (187 mg, 0.8 mmol, Example 3b) and N,N-diisopropylethylamine (0.28 mL, 1.6 mmol, Aldrich) were reacted under the conditions of Example 3c to give the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 461 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07582761B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-a5b79370abf1451baa3c44191cb46ddb |
| 出典メモ | uspto-grants-2009_09 |