反応式
[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[NH:6][C:7](Cl)=[N:8][C:4]=2[CH:3]=1.[Cl:12][C:13]1[C:14]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:15][CH:16]=[CH:17][CH:18]=1.C(N(CC)C(C)C)(C)C>>[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([N:22]3[CH2:23][CH2:24][N:19]([C:14]4[C:13]([Cl:12])=[CH:18][CH:17]=[CH:16][N:15]=4)[CH2:20][CH2:21]3)[NH:8][C:4]=2[CH:3]=1参加物
4
実験手順
The 5-bromo-2-chloro-1H-benzoimidazole (0.115 g, 0.5 mmol, Example 23b), 1-(3-chloropyridin-2-yl)piperazine (0.198 g, 1 mmo, Example 3b) and N,N-diisopropylethylamine (0.35 mL, 2 mmol, Aldrich) were reacted under the conditions of Example 3c to give the title compound as a white solid. M.p. 207-208° C. MS (ESI; pos.,ion) m/z: 394 (M+1).
出典と根拠
- ORDレコード
- ord-ab3b91e3b62343a1ba301a51a729d74f
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07582761B2
関連ノート
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