4-(5-Hydroxymethyl-3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester → (6-Piperazin-1-yl-5-trifluoromethyl-pyridin-3-yl)-methanol
反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:19]([C:20]([F:23])([F:22])[F:21])=[CH:18][C:17]([CH2:24][OH:25])=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>C(O)(C(F)(F)F)=O>[N:11]1([C:14]2[N:15]=[CH:16][C:17]([CH2:24][OH:25])=[CH:18][C:19]=2[C:20]([F:23])([F:21])[F:22])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1参加物
3
実験手順
4-(5-Hydroxymethyl-3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester from step (d) above (1.08 g, 3.0 mmol) reacted with TFA (10 mL, Aldrich) under the conditions of Example 183 g to give the title compound as a white solid. MS (ESI, pos. ion) m/e: 262 (M+1).
出典と根拠
- ORDレコード
- ord-b97b4d4bac974ffdb3d87c07174b4ac7
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07582761B2
反応ノート
読み込み中…