Aluminium lithium hydride → (1-Cyclopropyl-1H-indazol-5-yl) methanol
反応式
[CH:1]1([N:4]2[C:12]3[C:7](=[CH:8][C:9]([C:13](OC)=[O:14])=[CH:10][CH:11]=3)[CH:6]=[N:5]2)[CH2:3][CH2:2]1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[CH:1]1([N:4]2[C:12]3[C:7](=[CH:8][C:9]([CH2:13][OH:14])=[CH:10][CH:11]=3)[CH:6]=[N:5]2)[CH2:3][CH2:2]1参加物
4
実験手順
To a stirred solution of methyl 1-cyclopropyl-1H-indazole-5-carboxylate (400 mg, 1.8 mmol, step-1 of Example 28) in THF (15 mL) was added LiAlH4 (70 mg, 1.8 mmol) at 0° C. The reaction mixture was stirred for 1 hr at room temperature, and quenched with saturated aqueous NH4Cl (20 mL). The mixture was diluted with DCM (80 mL), dried over Na2SO4, filtered through a pad of Celite (registered trademark) the filtrate was concentrated to give 386 mg (quant.) of the titled compound as pale yellow oil.
後処理
- customquenched with saturated aqueous NH4Cl (20 mL)
- additionThe mixture was diluted with DCM (80 mL)
- dry with materialdried over Na2SO4
- filtrationfiltered through a pad of Celite (registered trademark) the filtrate
- concentrationwas concentrated
出典と根拠
- ORDレコード
- ord-ffe41fb35518440f99abb7e853bdc907
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08829026B2
反応ノート
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