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Triacetoxyperiodinane → (1-Methyl-1H-imidazol-5-yl)(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triacetoxyperiodinane | HCID 159087 | — |
| 反応物 | (1-Methyl-1H-imidazol-5-yl)(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)methanol | HCID 57835802 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (1-Methyl-1H-imidazol-5-yl)(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)methanone | HCID 57835849 | 23% |
反応手順
Dess-Martin periodinane (21 g, 50 mmol) was added to a solution of 74.1 (14 g crude, ˜50 mmol) in DCM (200 mL). After 1 hour, the reaction mixture was concentrated with silica gel and chromatographed (silica gel, 1:2 EtOAc/hexane) to provide compound 74.2 (3.3 g, 11.5 mmol). MS ESI (pos.) m/e: 287.1 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07582803B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-5f2f0d15a7264c1d84aa742d7a4b6a83 |
| 出典メモ | uspto-grants-2009_09 |