2-Aminothiazole → N,N-Dicyclopentyl-N'-1,3-thiazol-2-ylurea

HRID 731401

反応式

HRID 731401 の反応式
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[C:7](N1C=CN=C1)(N1C=CN=C1)=[O:8].CN(C1C=CC=CN=1)C.[CH:28]1([NH:33][CH:34]2[CH2:38][CH2:37][CH2:36][CH2:35]2)[CH2:32][CH2:31][CH2:30][CH2:29]1>ClCCl.C(OCC)(=O)C>[CH:34]1([N:33]([CH:28]2[CH2:29][CH2:30][CH2:31][CH2:32]2)[C:7]([NH:1][C:2]2[S:3][CH:4]=[CH:5][N:6]=2)=[O:8])[CH2:35][CH2:36][CH2:37][CH2:38]1

参加物

7

反応物 4

HCID 21552-AminothiazoleHCID 218852-DimethylaminopyridineHCID 682631,1'-CarbonyldiimidazoleHCID 247671Dicyclopentylamine

生成物 1

HCID 57688319N,N-Dicyclopentyl-N'-1,3-thiazol-2-ylurea

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 2-aminothiazole (50 mg, 0.5 mmol) in dichloromethane was added carbonyldiimidazole (81 mg, 0.5 mmol) and dimethylaminopyridine (3 mg) and the solution stirred 1 h at room temperature. Dicyclopentylamine (77 mg) was then added and the reaction stirred overnight at room temperature. The reaction mixture is then diluted with ethyl acetate (8 mL), washed successively with 10% sodiumhydrogensulphate (3 mL), water (3 mL), dried over magnesium sulphate, concentrated in vacuo, and the residue purified by flash chlomatography (eluant 7 ethyl acetate:3 heptane)

後処理

  1. stirringthe reaction stirred overnight at room temperature
  2. washwashed successively with 10% sodiumhydrogensulphate (3 mL), water (3 mL)
  3. dry with materialdried over magnesium sulphate
  4. concentrationconcentrated in vacuo
  5. customthe residue purified by flash chlomatography (eluant 7 ethyl acetate:3 heptane)

出典と根拠

ORDレコード
ord-a25127cea0ca4f5ab6f9881ba3e33f5d
出典データセット
uspto-grants-2009_09
特許番号
US07582769B2

関連ノート

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