Hydrochloric Acid → HCID 58080194、化合物
反応式
[NH2:1][C@@H:2]([CH2:9][S:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:3][C:4]([N:6]([CH3:8])[CH3:7])=O.CO.Cl>C1COCC1>[NH2:1][C@@H:2]([CH2:9][S:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[CH2:3][CH2:4][N:6]([CH3:8])[CH3:7]参加物
5
実験手順
A solution of EXAMPLE 1L (8.68 g, 36.5 mmol) in THF (200 mL) was treated with BH3-dimethylsulfide (18.2 mL, 182.5 mmol) at room temperature, stirred overnight, treated slowly with methanol (20 mL), followed by 2N HCl (50 mL), stirred overnight, and concentrated. The resulting residue was purified by silica gel chromatography eluting with 5% 7N NH3/CH3OH in dichloromethane to give the desired product (4.50 g, 55%). MS (CI) m/e 224 (M+H)+.
後処理
- stirringstirred overnight
- concentrationconcentrated
- customThe resulting residue was purified by silica gel chromatography
- washeluting with 5% 7N NH3/CH3OH in dichloromethane
出典と根拠
- ORDレコード
- ord-991bf97da32b4c229899f08f97064be6
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07585858B2
反応ノート
読み込み中…