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Morpholine → Benzyl (1r)-1-(hydroxymethyl)-3-(4-morpholinyl)-3-oxopropylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | (R)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate | HCID 697924 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | Benzyl (1r)-1-(hydroxymethyl)-3-(4-morpholinyl)-3-oxopropylcarbamate | HCID 59186710 | 86% |
反応手順
A solution of EXAMPLE 21B (13.5 g, 57.4 mmol) and morpholine (10.0 mL, 115 mmol) in dioxane (100 mL) was stirred at 70° C. for 18 hours. The solution was concentrated and purified by silica gel chromatography eluting with 10% methanol/ethyl acetate to provide the desired product 6.0 g, 86%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07585858B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-bff9c613403b4e95be6fe0c912eb22be |
| 出典メモ | uspto-grants-2009_09 |