Potassium Nitrate → 2,3-Dichloro-6-nitrobenzaldehyde

HRID 731676

反応式

HRID 731676 の反応式
[N+:1]([O-:4])([O-])=[O:2].[K+].[Cl:6][C:7]1[C:14]([Cl:15])=[CH:13][CH:12]=[CH:11][C:8]=1[CH:9]=[O:10]>S(=O)(=O)(O)O>[Cl:6][C:7]1[C:14]([Cl:15])=[CH:13][CH:12]=[C:11]([N+:1]([O-:4])=[O:2])[C:8]=1[CH:9]=[O:10]

参加物

4

反応物 2

HCID 24434Potassium NitrateHCID 357452,3-Dichlorobenzaldehyde

生成物 1

HCID 112182712,3-Dichloro-6-nitrobenzaldehyde収率 34.5%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

Potassium nitrate (578 mg, 5.71 mmol) was dissolved in concentrated sulfuric acid (4.5 mL) and added dropwise to a stirred solution of 2,3-dichlorobenzaldehyde (1.0 g, 5.71 mmol) at room temperature. The mixture was left without stirring for 10 days at room temperature. Material that had crystallized out of the reaction mixture was collected by filtration to afford 2,3-dichloro-6-nitrobenzaldehyde (196MBT36, 433 mg, 34%) as yellow needles. Regioselectivity was confirmed by the Bayer-Drewson indigo synthesis.

後処理

  1. waitThe mixture was left
  2. customMaterial that had crystallized out of the reaction mixture
  3. filtrationwas collected by filtration

出典と根拠

ORDレコード
ord-5e952184a2824600b6a45a378c0af399
出典データセット
uspto-grants-2009_09
特許番号
US07585877B2

関連ノート

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