Dichloromethane → 3-Ethoxy-4-methoxybenzoyl chloride

HRID 731894ノート

反応式

HRID 731894 の反応式
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[C:7](O)=[O:8])[CH3:2].C(Cl)[Cl:16].C(Cl)(=O)C(Cl)=O>CN(C=O)C.C1C=CC=CC=1>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[C:7]([Cl:16])=[O:8])[CH3:2]

参加物

6

反応物 3

HCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 28229573-Ethoxy-4-methoxybenzoic acid

生成物 1

HCID 450812503-Ethoxy-4-methoxybenzoyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 241Benzene溶媒

実験手順

3-ethoxy-4-methoxybenzoic acid (5 g, 25.5 mmol) was added to a solution of CH2Cl2 (40 mL) and benzene (20 mL) in a flame-dried 150 mL round bottom flask. Anhydrous DMF (9 drops) was added and the solution was cooled on ice. Oxalyl chloride (11 mL, 128 mmol) was added dropwise, and the reaction was then allowed to warm to RT. The reaction was stirred at RT for 90 minutes, then concentrated in vacuo yield an off-white solid. The solid was placed on a high-vacuum line for 2 hours, and then taken onto the next step without further characterization.

後処理

  1. temperaturethe solution was cooled on ice
  2. concentrationconcentrated in vacuo
  3. customyield an off-white solid
  4. waitThe solid was placed on a high-vacuum line for 2 hours

出典と根拠

ORDレコード
ord-0c5c7d45b0bd4138811a8adb856b8e35
出典データセット
uspto-grants-2009_09
特許番号
US07585868B2

反応ノート

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