反応式
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH:15]([NH2:17])[CH3:16].FC1C=C(F)C=CC=1[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[C:32](=[O:34])C.C([O-])(=[O:37])C.[NH4+].C([BH3-])#N.[Na+]>CO>[F:8][C:6]1[CH:7]=[CH:2][C:3]2[C:9]3[C:10]([CH:15]([CH3:16])[N:17]([C:32]([C:27]4[CH:28]=[C:29]([OH:37])[CH:30]=[CH:31][CH:26]=4)=[O:34])[C:4]=2[CH:5]=1)=[CH:11][CH:12]=[CH:13][CH:14]=3参加物
6
実験手順
1-(-2′,4′-difluoro-biphenyl-2-yl)-ethylamine—The title compound was prepared from 1-(2′,4′-difluoro-1,1′-biphenyl-2-yl)ethanone (3.67 g, 15.8 mmol), anhydrous methanol (200 mL), ammonium acetate (12.2 g, 158 mmol), and sodium cyanoborohydride (1.99 g, 31.6 mmol) according to the procedure and in the same manner as described in Example 24, step b resulting in the isolation of a clear oil that was used without further purification. MS [(ES+), m/z]: 217 [M-16]+, benzylic cation as a result of the loss of NH2.
後処理
- customresulting in the isolation of a clear oil that
- customwas used without further purification
- customMS [(ES+), m/z]: 217 [M-16]+, benzylic cation as a result of the loss of NH2
出典と根拠
- ORDレコード
- ord-1b36fa801b1d4d6c9ac0302aa85ce949
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07585871B2
関連ノート
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