Hydrazine hydrate (1:1) → 3-Cyanobenzohydrazide

HRID 732027

反応式

HRID 732027 の反応式
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]#[N:11])[CH:5]=1.O.[NH2:14][NH2:15]>C(O)C>[C:10]([C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=1)[C:3]([NH:14][NH2:15])=[O:2])#[N:11]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 83554Benzoic acid, 3-cyano-, methyl ester

生成物 1

HCID 219426583-Cyanobenzohydrazide収率 52.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 3-cyano-benzoic acid methyl ester (2 g, 12 mmol) and hydrazine monohydrate (0.60 mL, 12 mmol) in ethanol (10 mL) was stirred at room temperature overnight. The reaction mixture was concentrated and then the residue was triturated with diethyl ether to afford 3-cyano-benzoic acid hydrazide (1.02 g, 51%, pink solid). 1H NMR (DMSO) □ (ppm): 10.31 (s, 1H), 8.21 (m, 1H), 8.11 (m, 1H), 7.99 (m, 1H), 7.70 (m, 1H), 4.50 (s, 1H).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was triturated with diethyl ether

出典と根拠

ORDレコード
ord-9de038fd9408409d98c15b6450e01aa9
出典データセット
uspto-grants-2009_09
特許番号
US07585881B2

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