Sodium Hydroxide → 3-(3-Cyclopropyl-2-pyridin-4-yl-3H-imidazol-4-yl)-2-methyl-propionic acid

HRID 732102ノート

反応式

HRID 732102 の反応式
C([O:3][C:4](=[O:22])[CH:5]([CH3:21])[CH2:6][C:7]1[N:8]([CH:18]2[CH2:20][CH2:19]2)[C:9]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[N:10][CH:11]=1)C.[OH-].[Na+]>CO>[CH:18]1([N:8]2[C:7]([CH2:6][CH:5]([CH3:21])[C:4]([OH:22])=[O:3])=[CH:11][N:10]=[C:9]2[C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[CH2:19][CH2:20]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 578379853-(3-cyclopropyl-2-pyridin-4-yl-3H-imidazol-4-yl)-2-methyl-propionic acid ethyl ester

生成物 1

HCID 578379903-(3-Cyclopropyl-2-pyridin-4-yl-3H-imidazol-4-yl)-2-methyl-propionic acid収率 76.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3-(3-cyclopropyl-2-pyridin-4-yl-3H-imidazol-4-yl)-2-methyl-propionic acid ethyl ester (1.02 g, 3.40 mmol) was mixed with MeOH (8 ml) and sodium hydroxide (1N in water, 5.1 ml, 5.10 mmol). This mixture was left stirring at r.t. for 5 h, followed by concentration in-vacuo. The isolated residue was treated with aq. HCl (2N, 6 ml) to isolate the title compound (702 mg, 76%). 1H-NMR (DMSO-d6): 8.63 (dd, 2H), 7.74 (dd, 2H), 6.82 (s, 1H), 3.55 (m, 1H), 3.09 (m, 1H), 2.82 (m, 2H), 1.19 (d, 3H), 1.08 (m, 2H), 0.56 (m, 2H).

後処理

  1. waitThis mixture was left
  2. concentrationfollowed by concentration in-vacuo
  3. additionThe isolated residue was treated with aq. HCl (2N, 6 ml)

出典と根拠

ORDレコード
ord-e2effea10bbe433ea6023d818120c84e
出典データセット
uspto-grants-2009_09
特許番号
US07585881B2

反応ノート

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