Benzenepropanoic acid, 4-hydroxy-, methyl ester → Methyl 3-{4-[(4-{[(4-phenyl-1,3-thiazol-2-yl)(2-pyridin-2-ylethyl)amino]methyl}benzyl)oxy]phenyl}propanoate

HRID 732210

反応式

HRID 732210 の反応式
[C:1]1([C:7]2[N:8]=[C:9]([N:12]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([CH2:28][OH:29])=[CH:24][CH:23]=3)[CH2:13][CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O[C:31]1[CH:36]=[CH:35][C:34]([CH2:37][CH2:38][C:39]([O:41][CH3:42])=[O:40])=[CH:33][CH:32]=1>>[C:1]1([C:7]2[N:8]=[C:9]([N:12]([CH2:21][C:22]3[CH:23]=[CH:24][C:25]([CH2:28][O:29][C:31]4[CH:36]=[CH:35][C:34]([CH2:37][CH2:38][C:39]([O:41][CH3:42])=[O:40])=[CH:33][CH:32]=4)=[CH:26][CH:27]=3)[CH2:13][CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[S:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

3

反応物 2

HCID 79706Benzenepropanoic acid, 4-hydroxy-, methyl esterHCID 23143295(4-([(4-Phenyl-1,3-thiazol-2-yl)(2-pyridin-2-ylethyl)amino]methyl}phenyl)methanol

生成物 1

HCID 23143288Methyl 3-{4-[(4-{[(4-phenyl-1,3-thiazol-2-yl)(2-pyridin-2-ylethyl)amino]methyl}benzyl)oxy]phenyl}propanoate収率 57%

実験手順

The title compound was synthesized in the same manner as in Example 8 from (4-{[(4-phenyl-1,3-thiazol-2-yl)(2-pyridin-2-ylethyl)amino]methyl}phenyl)methanol and methyl 3-(4-hydroxyphenyl)propanoate by Mitsunobu reaction (yield 57%). Yellow oil.

出典と根拠

ORDレコード
ord-0eb6a71bc6ad415ea62f9cdb7fbd562b
出典データセット
uspto-grants-2009_09
特許番号
US07585880B2

関連ノート

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