HCID 58138925、化合物 → HCID 58138929、化合物
反応式
[F:1][C:2]([F:16])([F:15])[C:3]1[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([C:12]#[N:13])=[CH:7][C:6]=2[Br:14]>C1COCC1>[F:16][C:2]([F:1])([F:15])[C:3]1[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([CH2:12][NH2:13])=[CH:7][C:6]=2[Br:14]参加物
3
実験手順
A solution of 2-(trifluoromethyl)-5-cyano-7-bromo-1H-indole (Intermediate 4, 200 mg) in THF (10 mL) cooled in an ice-water bath was treated with borane tetrahydrofuran complex (1.52 mL) dropwise via a syringe and stirred under argon for 18 hrs while allowing to warm to room temp. The reaction mixture was then quenched with methanol (5 mL) and stirred at room temperature for 10 min. The reaction mixture was then evaporated to dryness to give the title compound as a white foam (230 mg), which was used in the next step without further purification;
後処理
- additionwas treated with borane tetrahydrofuran complex (1.52 mL) dropwise via a syringe
- customThe reaction mixture was then quenched with methanol (5 mL)
- stirringstirred at room temperature for 10 min
- customThe reaction mixture was then evaporated to dryness
出典と根拠
- ORDレコード
- ord-01cd1980e8b54705a7a31db1c379ac08
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08829031B2
反応ノート
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