Propanal → 4-Nitro-3-hexanol
反応式
[N+:1](CCC)([O-:3])=[O:2].[O:7]1[CH2:11][CH2:10][CH2:9][CH2:8]1.N12CCCN=C1CCC[CH2:14][CH2:13]2.C(=O)CC>C(OCC)(=O)C>[OH:7][CH:8]([CH2:13][CH3:14])[CH:9]([N+:1]([O-:3])=[O:2])[CH2:10][CH3:11]参加物
6
実験手順
Into a reaction vessel purged with nitrogen, 1-nitropropane (8.93 ml, 100 mmol) and dehydrated tetrahydrofuran (dry THF) (50 ml) were added. After 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) (1.5 ml, 10 mmol) was added, propionaldehyde (4.68 ml, 100 mmol) was added while cooling in an ice bath. After stirring for 10 hours at room temperature, ethyl acetate (100 ml) was added. The resulting solution was washed using dilute hydrochloric acid, water and saturated saline, and the obtained organic layer was dried over anhydrous sodium sulfate. The resulting solution was concentrated under reduced pressure to give 4-hydroxy-3-nitrohexane (12.33 g, yield 84%)
後処理
- additionwere added
- temperaturewhile cooling in an ice bath
- washThe resulting solution was washed
- dry with materialthe obtained organic layer was dried over anhydrous sodium sulfate
- concentrationThe resulting solution was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-7a86a1c25ad648bfa7d1c7a5b08fe20c
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07586117B2
反応ノート
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