Hydrochloric Acid → 3-Iodo-5-(methoxycarbonyl)benzoic acid

HRID 732544ノート

反応式

HRID 732544 の反応式
[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:13]=[C:12]([I:14])[CH:11]=[C:6]([C:7]([O:9]C)=[O:8])[CH:5]=1.[OH-].[Na+].Cl>CO>[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:13]=[C:12]([I:14])[CH:11]=[C:6]([C:7]([OH:9])=[O:8])[CH:5]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 2758568Dimethyl 5-iodoisophthalate

生成物 1

HCID 158403913-Iodo-5-(methoxycarbonyl)benzoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
0 °C

実験手順

Dissolve 5-iodo-isophthalic acid dimethyl ester (10 g, 31.2 mmol) in methanol (90 mL) and cool to 0° C. Add 2 N NaOH (15.6 mL) dropwise and slowly warm up to room temperature. Stir overnight and acidify to about pH=3 with 5 N HCl. Extract with ethyl acetate (2×50 mL). Wash the combined organic layers by water, saturated aqueous sodium chloride, dry (magnesium sulfate) and concentrate to give the title compound as a crude residue which is used in the next step without further purification.

後処理

  1. temperatureslowly warm up to room temperature
  2. extractionExtract with ethyl acetate (2×50 mL)
  3. washWash the combined organic layers by water, saturated aqueous sodium chloride
  4. dry with materialdry (magnesium sulfate)
  5. concentrationconcentrate

出典と根拠

ORDレコード
ord-bfea2f8ccae749d79ddea5a508e31d0e
出典データセット
uspto-grants-2009_09
特許番号
US07585885B2

反応ノート

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