Hydrochloric Acid → HCID 68814780、化合物

HRID 732561ノート

反応式

HRID 732561 の反応式
C[O:2][C:3](=[O:22])[C:4]1[CH:16]=[C:15](C(=O)C(C)C)[CH:14]=[C:6]([C:7]([N:9]([CH3:13])[CH2:10][CH2:11][CH3:12])=[O:8])[CH:5]=1.[OH-:23].[Na+].Cl>CO>[C:3]([C:5]1[C:6]([C:7]([N:9]([CH3:13])[CH2:10][CH2:11][CH3:12])=[O:8])=[CH:14][CH:15]=[CH:16][C:4]=1[C:3]([OH:2])=[O:22])(=[O:23])[CH:4]([CH3:16])[CH3:5]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68814779HCID 68814779、化合物

生成物 1

HCID 68814780HCID 68814780、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Dissolve 5-isobutyryl-N-methyl-N-propyl-isophthalamic acid methyl ester (50 mg, 0.16 mmol) in methanol (3 mL) and add dropwise 2 N NaOH (0.16 mL). Stir the mixture at room temperature for 6 h, store overnight at 4° C. and acidify to about pH=6 by 5 N HCl. Concentrate to near dryness and dilute the residue with ethyl acetate. Wash with saturated aqueous sodium chloride solution and extract the organic layer, dry (magnesium sulfate) and concentrate to give the title compound.

後処理

  1. waitstore overnight at 4° C.
  2. concentrationConcentrate
  3. additiondilute the residue with ethyl acetate
  4. washWash with saturated aqueous sodium chloride solution
  5. extractionextract the organic layer
  6. dry with materialdry (magnesium sulfate)
  7. concentrationconcentrate

出典と根拠

ORDレコード
ord-2eb32b244a384d9fb7c9d3798f9a92d3
出典データセット
uspto-grants-2009_09
特許番号
US07585885B2

反応ノート

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