化工社化工社 化学情報印刷レポート · 研究参考用
tert-Butyldimethylsilyl chloride → 1-Benzyl-3-t-butyldimethylsilyloxymethylpyrrolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | (1-Benzylpyrrolidin-3-yl)methanol | HCID 5176654 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 1-Benzyl-3-t-butyldimethylsilyloxymethylpyrrolidine | HCID 19914927 | — |
反応手順
Diisopropylethylamine and tert-butyldimethyl-chlorosilane were added in that order to a chloroform solution of (1-benzylpyrrolidin-3-yl)methanol and stirred at room temperature for 5Hours. Thereafter, its work-up and purification were carried out in the standard method to obtain 1-benzyl-3-({[tert-butyl(dimethyl)silyl]oxy}methyl]pyrrolidine. EP: 306.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07585886B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-22633246d1ab409e8e61f01d745b9caa |
| 出典メモ | uspto-grants-2009_09 |