Hydrochloric Acid → 2-[4-(1-amino-1-methylethyl)phenyl]-3-(2-thienyl)-1,6-naphthyridin-5(6H)-one

HRID 732875ノート

反応式

HRID 732875 の反応式
C[O:2][C:3]1[N:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[C:6]([C:23]1[S:24][CH:25]=[CH:26][CH:27]=1)[C:7]([C:13]1[CH:18]=[CH:17][C:16]([C:19]([NH2:22])([CH3:21])[CH3:20])=[CH:15][CH:14]=1)=[N:8]2.Cl>C1COCC1>[NH2:22][C:19]([C:16]1[CH:15]=[CH:14][C:13]([C:7]2[C:6]([C:23]3[S:24][CH:25]=[CH:26][CH:27]=3)=[CH:5][C:4]3[C:3](=[O:2])[NH:12][CH:11]=[CH:10][C:9]=3[N:8]=2)=[CH:18][CH:17]=1)([CH3:21])[CH3:20]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 690592742-{4-[5-Methoxy-3-(2-thienyl)-1,6-naphthyridin-2-yl]phenyl}propan-2-amine

生成物 1

HCID 118549652-[4-(1-amino-1-methylethyl)phenyl]-3-(2-thienyl)-1,6-naphthyridin-5(6H)-one

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 2-{4-[5-methoxy-3-(2-thienyl)-1,6-naphthyridin-2-yl]phenyl}propan-2-amine (2-6, 66 mg, 0.176 mmol) in THF (10 mL) was added concentrated HCl (1 mL) and stirred for 5 h at rt. The volatiles were evaporated in vacuo and the residue was partitioned between saturated sodium bicarbonate solution and ethyl acetate. The organic layer was dried over magnesium sulfate, filtered, and concentrated to give the title compound as an off-white solid. LRMS m/z (M+1) Calcd: 362.1,. Found 362.2.

後処理

  1. customThe volatiles were evaporated in vacuo
  2. customthe residue was partitioned between saturated sodium bicarbonate solution and ethyl acetate
  3. dry with materialThe organic layer was dried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-4a54003a015341c3b62e272e9fcddc62
出典データセット
uspto-grants-2009_09
特許番号
US07589068B2

反応ノート

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