Ethanol → Ethyl 4-fluoro-2-hydroxybenzoate

HRID 73317

反応式

HRID 73317 の反応式
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([OH:11])[CH:3]=1.S(Cl)(Cl)=O.[CH2:16](O)[CH3:17]>>[CH2:16]([O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([F:1])=[CH:3][C:4]=1[OH:11])[CH3:17]

参加物

4

反応物 3

HCID 702EthanolHCID 24386Thionyl ChlorideHCID 676614-Fluorosalicylic acid

生成物 1

HCID 22478444Ethyl 4-fluoro-2-hydroxybenzoate

実験手順

To a solution of 4-fluoro-2-hydroxybenzoic acid (3.0 g) in ethanol (40 mL) was added thionyl chloride (5.61 mL) at 0° C., and the mixture was heated under reflux for 24 hours. The reaction mixture was concentrated under reduced pressure. This residue was poured into water, and the resulting mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give the title compound (3.5 g).

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 24 hours
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. additionThis residue was poured into water
  5. extractionthe resulting mixture was extracted with ethyl acetate
  6. washThe organic layer was washed with water and brine
  7. dry with materialdried over anhydrous magnesium sulfate
  8. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-7659cbae769d450f8f537268ffb4e0b9
出典データセット
uspto-grants-2014_09
特許番号
US08829040B2

関連ノート

読み込み中…