Methyl iodide → HCID 178503548、化合物
反応式
[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][C:12]1[N:17]=[C:16]([SH:18])[N:15]=[C:14]([OH:19])[CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].[CH3:22]I>>[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][C:12]1[N:17]=[C:16]([S:18][CH3:22])[N:15]=[C:14]([OH:19])[CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
A mixture of 6-(3-benzyloxy-propyl)-2-mercapto-pyrimidin-4-ol (7.94 g), potassium hydroxide (32 mL of 1N solution in methanol) and methyl iodide (1.97 mL) was stirred at room temperature overnight. The precipitate was filtered, washed successively with methanol (2×20 mL), isopropanol (2×20 mL) and water (2×20 mL), then dried to afford 6-(3-benzyloxy-propyl)-2-methylsulfanyl-pyrimidin-4-ol as a white powder (7.0 g). MS m/z 291.0 (M+1), 100%.
後処理
- filtrationThe precipitate was filtered
- washwashed successively with methanol (2×20 mL), isopropanol (2×20 mL) and water (2×20 mL)
- custom