Hydroxylamine → 6-Fluoro-1H-indole-3-carbonitrile

HRID 73322

反応式

HRID 73322 の反応式
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:11]=O)=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[NH2:13]O.C([O-])=O.[Na+].O>C(O)=O>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]#[N:13])=[CH:7][NH:8]2)=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 787HydroxylamineHCID 962WaterHCID 2629036-Fluoroindole-3-carboxaldehydeHCID 2723810Sodium Formate

生成物 1

HCID 534187306-Fluoro-1H-indole-3-carbonitrile収率 59.9%

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

反応条件

温度
100 °C

実験手順

To a solution of 6-fluoro-1H-indole-3-carbaldehyde (0.97 g) in 90% formic acid (25 mL) were added hydroxylamine (0.65 g) and sodium formate (0.81 g), and this mixture was stirred at 100° C. for 3 hours. After cooling to ambient temperature, water was added to this reaction mixture and the precipitated solid was collected by filtration, and washed with water, dried to give the title compound (0.57 g).

後処理

  1. temperatureAfter cooling to ambient temperature
  2. filtrationthe precipitated solid was collected by filtration
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-111bd519c84a4f52ada23e687209d777
出典データセット
uspto-grants-2014_09
特許番号
US08829040B2

関連ノート

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