Methyl iodide → HCID 57840842、化合物

HRID 733685ノート

反応式

HRID 733685 の反応式
[Br:1][C:2]1[C:7]2[CH:8]=[CH:9][NH:10][C:6]=2[C:5]([Br:11])=[CH:4][N:3]=1.IC.[C:14](=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:1][C:2]1[C:7]2[CH:8]=[CH:9][N:10]([CH3:14])[C:6]=2[C:5]([Br:11])=[CH:4][N:3]=1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 247294414,7-Dibromo-1H-pyrrolo[3,2-c]pyridine

生成物 1

HCID 57840842HCID 57840842、化合物収率 69.8%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 4,7-dibromo-1H-pyrrolo[3,2-c]pyridine (1.35 g), iodomethane (609 ul) and anhydrous potassium carbonate (1.35 g) in dry acetone (90 ml) was refluxed overnight. The mixture was evaporated and the residue added to ethyl acetate (60 ml) and water (60 ml). The organic layer was washed with water then brine, dried (MgSO4) and evaporated. Purification of the residue by chromatography on silica gel, eluting with dichloromethane, gave the title compound (0.99 g)

後処理

  1. temperaturewas refluxed overnight
  2. customThe mixture was evaporated
  3. additionthe residue added to ethyl acetate (60 ml) and water (60 ml)
  4. washThe organic layer was washed with water
  5. dry with materialbrine, dried (MgSO4)
  6. customevaporated
  7. customPurification of the residue by chromatography on silica gel
  8. washeluting with dichloromethane

出典と根拠

ORDレコード
ord-3e339e066128492897a344712ee1f386
出典データセット
uspto-grants-2009_09
特許番号
US07589206B2

反応ノート

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