Sodium Hydroxide → HCID 44475510、化合物
反応式
C[O:2][C:3]([C:5]1[C:6]2[N:21]([CH3:22])[CH:20]=[CH:19][C:7]=2[C:8]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=2)=[N:9][CH:10]=1)=[O:4].[OH-].[Na+]>CO>[Cl:18][C:14]1[CH:13]=[C:12]([NH:11][C:8]2[C:7]3[CH:19]=[CH:20][N:21]([CH3:22])[C:6]=3[C:5]([C:3]([OH:4])=[O:2])=[CH:10][N:9]=2)[CH:17]=[CH:16][CH:15]=1参加物
4
実験手順
4-(3-Chloro-phenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridine-7-carboxylic acid methyl ester (0.6 g) and 2N sodium hydroxide (2 ml) in methanol were irradiated at 120° C. for 3 minutes with microwaves. The solvent was evaporated and the residue partitioned between ethyl acetate and water. The organic layer washed with dilute citric acid solution and saturated brine solution then dried (MgSO4), filtered and evaporated to yield the title compound as an off-white solid (0.48 g).