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Morpholine → 4-(5-Bromopyrimidin-2-yl)morpholine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 5-Bromo-2-chloropyrimidine | HCID 606665 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-(5-Bromopyrimidin-2-yl)morpholine | HCID 5144362 | 35.7% |
反応手順
Potassium carbonate (0.34 g) was added to a solution of 2-chloro-5-bromo-pyrimidine (0.5 g) in DMF (20 ml). The reaction mixture was stirred at rt for 15 min. Morpholine (0.2 g) was added and the reaction mixture was stirred at rt for 2 h. The excess DMF was removed by evaporation and the residue was partitioned between H2O/EtOAc (30:30 ml) The EtOAc layer was dried (MgSO4) and evaporated to dryness to give the sub-title compound as a cream solid (0.2 g). LCMS electrospray(+ve) 246 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07592347B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-ab2a6236d2154eccafc76ab11566ee69 |
| 出典メモ | uspto-grants-2009_09 |