反应详情

Potassium carbonate (0.34 g) was added to a solution of 2-chloro-5-bromo-pyrimidine (0.5 g) in DMF (20 ml). The reaction mixture was stirred at rt for 15 min. Morpholine (0.2 g) was added and the reaction mixture was stirred at rt for 2 h. The excess DMF was removed by evaporation and the residue was partitioned between H2O/EtOAc (30:30 ml) The EtOAc layer was dried (MgSO4) and evaporated to dryness to give the sub-title compound as a cream solid (0.2 g). LCMS electrospray(+ve) 246 (MH+).

1. stirringthe reaction mixture was stirred at rt for 2 h
2. customThe excess DMF was removed by evaporation
3. customthe residue was partitioned between H2O/EtOAc (30:30 ml) The EtOAc layer
4. dry with materialwas dried (MgSO4)
5. customevaporated to dryness