HCID 68817418、化合物 → HCID 86068765、化合物

HRID 734732ノート

反応式

HRID 734732 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([CH2:9][OH:10])=[CH:4][C:3]=1[S:11]([NH2:14])(=[O:13])=[O:12]>CC(C)=O.O=[Mn]=O>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([CH:9]=[O:10])=[CH:4][C:3]=1[S:11]([NH2:14])(=[O:12])=[O:13]

参加物

4

反応物 1

HCID 68817418HCID 68817418、化合物

生成物 1

HCID 86068765HCID 86068765、化合物収率 60.1%

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 180Acetone溶媒

実験手順

A solution of 2-chloro-4-fluoro-5-(hydroxymethyl)benzenesulfonamide (440 mg, 1.84 mmol) in acetone (18 mL) was added to a round bottom flask containing MnO2 (1.60 g, 18.4 mmol). The mixture was stirred for 50 hours until the starting material was gone, then filtered though a pad of celite. The filtrate was evaporated to afford the product (263 mg, 60%) as a white solid. MS (ES+) m/z 238 [M+H]+.

後処理

  1. filtrationfiltered though a pad of celite
  2. customThe filtrate was evaporated

出典と根拠

ORDレコード
ord-400fce3e29ec4fe1807fbf20fa15f281
出典データセット
uspto-grants-2009_09
特許番号
US07592357B2

反応ノート

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