Methanol → Methyl 4-chloro-3-sulfamoylbenzoate
反応式
[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[CH3:15]O>S(=O)(=O)(O)O.CCOC(C)=O>[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([O:10][CH3:15])=[O:9])(=[O:4])=[O:3]参加物
5
実験手順
3-(Aminosulfonyl)-4-chlorobenzoic acid (943 mg, 4.0 mmol) was heated at 70° C. in CH3OH (10 mL) with 3 drops of concentrated sulfuric acid for 34 hours. The reaction mixture was diluted with EtOAc (20 mL), washed with water, brine, and dried (Na2SO4). The solvent was evaporated to afford the product (950 mg, 95%) as a white solid. MS (ES+) m/z 250 [M+H]+.
後処理
- washwashed with water, brine
- dry with materialdried (Na2SO4)
- customThe solvent was evaporated
出典と根拠
- ORDレコード
- ord-2ba078ff6fe9468996bc53adcbb229cd
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07592357B2
反応ノート
読み込み中…