Methanol → Methyl 4-chloro-3-sulfamoylbenzoate

HRID 734733

反応式

HRID 734733 の反応式
[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[CH3:15]O>S(=O)(=O)(O)O.CCOC(C)=O>[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([O:10][CH3:15])=[O:9])(=[O:4])=[O:3]

参加物

5

反応物 2

HCID 887MethanolHCID 145684-Chloro-3-sulfamoylbenzoic acid

生成物 1

HCID 4277179Methyl 4-chloro-3-sulfamoylbenzoate収率 95%

試薬・触媒・溶媒 2

HCID 1118Sulfuric Acid触媒HCID 8857Ethyl Acetate溶媒

実験手順

3-(Aminosulfonyl)-4-chlorobenzoic acid (943 mg, 4.0 mmol) was heated at 70° C. in CH3OH (10 mL) with 3 drops of concentrated sulfuric acid for 34 hours. The reaction mixture was diluted with EtOAc (20 mL), washed with water, brine, and dried (Na2SO4). The solvent was evaporated to afford the product (950 mg, 95%) as a white solid. MS (ES+) m/z 250 [M+H]+.

後処理

  1. washwashed with water, brine
  2. dry with materialdried (Na2SO4)
  3. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-2ba078ff6fe9468996bc53adcbb229cd
出典データセット
uspto-grants-2009_09
特許番号
US07592357B2

関連ノート

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