Methanol → Benzoic acid, 3-(aminosulfonyl)-, methyl ester

HRID 734736

反応式

HRID 734736 の反応式
[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[CH3:14]O>S(=O)(=O)(O)O.CCOC(C)=O>[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([O:10][CH3:14])=[O:9])(=[O:3])=[O:4]

参加物

5

反応物 2

HCID 887MethanolHCID 2293523-Sulfamoylbenzoic acid

生成物 1

HCID 108836Benzoic acid, 3-(aminosulfonyl)-, methyl ester収率 98%

試薬・触媒・溶媒 2

HCID 1118Sulfuric Acid触媒HCID 8857Ethyl Acetate溶媒

実験手順

3-(Aminosulfonyl)benzoic acid (603 mg, 3.0 mmol) was heated at 80° C. in CH3OH (3 mL) with 3 drops of concentrated sulfuric acid for 60 hours. The reaction mixture was diluted with EtOAc (20 mL), washed with water, brine, and dried (Na2SO4). The solvent was evaporated to afford the product (630 mg, 98%) as a white solid. MS (ES+) m/z 216 [M+H]+.

後処理

  1. washwashed with water, brine
  2. dry with materialdried (Na2SO4)
  3. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-a4b72a81d93e43e8aa724688c2f86acf
出典データセット
uspto-grants-2009_09
特許番号
US07592357B2

関連ノート

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