1-Benzyl-4-(trifluoromethyl)piperidin-4-ol → 4-(Trifluoromethyl)-4-piperidinol
反応式
C([N:8]1[CH2:13][CH2:12][C:11]([C:15]([F:18])([F:17])[F:16])([OH:14])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[F:18][C:15]([F:16])([F:17])[C:11]1([OH:14])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1参加物
5
実験手順
A suspension of 6.48 g (25.00 mmol) of 1-benzyl-4-trifluoromethylpiperidin-4-ol and 810 mg Pd/C (10%) in 100 mL of MeOH was hydrogenated at RT and 3 bar hydrogen pressure for 17 hours. The catalyst was filtered off and the filtrate evaporated down in vacuo. Yield: 4.22 g (quant. yield); C6H10F3NO (M=169.145); calc.: molpeak (M+H)+: 170; found: molpeak (M+H)+: 17; Rf value: 0.00 (silica gel, cyc/EtOAc 2:1).
後処理
- customwas hydrogenated at RT
- filtrationThe catalyst was filtered off
- customthe filtrate evaporated down in vacuo
出典と根拠
- ORDレコード
- ord-ab68702b99324b55b38f6f38ef6bd6e7
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07592358B2
反応ノート
読み込み中…